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1

Pharmacodynamics and Pharmacokinetics of the HMG-CoA Reductase Inhibitors

Dr Hans Lennernäs, Gunnar Fager

Journal:

Clinical Pharmacokinetics

Année:

1997

Langue:

english

Fichier:

PDF, 3.60 MB

english, 1997

2

Intestinal Permeability and Drug Absorption: Predictive Experimental, Computational and In Vivo Approaches

Dahlgren, David, Lennernäs, Hans

Journal:

Année:

2019

Langue:

english

Fichier:

PDF, 1.34 MB

english, 2019

3

The Effects of Food on the Dissolution of Poorly Soluble Drugs in Human and in Model Small Intestinal Fluids

Eva M. Persson, Ann-Sofie Gustafsson, Anders S. Carlsson, Ralf G. Nilsson, Lars Knutson, Patrick Forsell, Gunilla Hanisch, Hans Lennernäs, Bertil Abrahamsson

Journal:

Pharmaceutical Research

Année:

2005

Langue:

english

Fichier:

PDF, 484 KB

english, 2005

4

The BCS, BDDCS, and Regulatory Guidances

Mei-Ling Chen, Gordon L. Amidon, Leslie Z. Benet, Hans Lennernas, Lawrence X. Yu

Journal:

Pharmaceutical Research

Année:

2011

Langue:

english

Fichier:

PDF, 124 KB

english, 2011

5

A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation ofin VitroDrug Product Dissolution andin VivoBioavailability

Gordon L. Amidon, Hans Lennernäs, Vinod P. Shah, John R. Crison

Journal:

Pharmaceutical Research

Année:

1995

Fichier:

PDF, 1.34 MB

1995

6

Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment

Tannergren, Christer, Bergendal, Anna, Lennernäs, Hans, Abrahamsson, Bertil

Journal:

Molecular Pharmaceutics

Année:

2009

Langue:

english

Fichier:

PDF, 178 KB

english, 2009

7

Adrenal insufficiency: review of clinical outcomes with current glucocorticoid replacement therapy

Johannsson, Gudmundur, Falorni, Alberto, Skrtic, Stanko, Lennernäs, Hans, Quinkler, Marcus, Monson, John P., Stewart, Paul M.

Journal:

Clinical Endocrinology

Année:

2015

Langue:

english

Fichier:

PDF, 295 KB

english, 2015

8

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || High-Throughput Measurement of log D and pKa

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Année:

2003

Langue:

english

Fichier:

PDF, 372 KB

english, 2003

9

In Vivo Predictive Dissolution (IPD) and Biopharmaceutical Modeling and Simulation: Future Use of Modern Approaches and Methodologies in a Regulatory Context

Lennernäs, H., Lindahl, A., Van Peer, A., Ollier, C., Flanagan, T., Lionberger, R., Nordmark, A., Yamashita, S., Yu, L., Amidon, G. L., Fischer, V., Sjögren, E., Zane, P., McAllister, M., Abrahamsson,

Journal:

Molecular Pharmaceutics

Année:

2017

Langue:

english

Fichier:

PDF, 698 KB

english, 2017

10

Hydrogen bonding descriptors in the prediction of human in vivo intestinal permeability

Susanne Winiwarter, Fredrik Ax, Hans Lennernäs, Anders Hallberg, Curt Pettersson, Anders Karlén

Journal:

Journal of Molecular Graphics and Modelling

Année:

2003

Langue:

english

Fichier:

PDF, 543 KB

english, 2003

11

Endocrine responses to nocturnal eating – possible implications for night work

Ulf Holmbäck, Anders Forslund, Arne Lowden, Jeanette Forslund, Torbjörn Åkerstedt, Maria Lennernäs, Leif Hambraeus, Mats Stridsberg

Journal:

European Journal of Nutrition

Année:

2003

Langue:

english

Fichier:

PDF, 468 KB

english, 2003

12

Dissolution of Hydrocortisone in Human and Simulated Intestinal Fluids

Betty Lomstein Pedersen, Helle Brøndsted, Hans Lennernäs, Finn Norring Christensen, Anette Müllertz, Henning Gjelstrup Kristensen

Journal:

Pharmaceutical Research

Année:

2000

Langue:

english

Fichier:

PDF, 151 KB

english, 2000

13

Jejunal Permeability: A Comparison Between the Ussing Chamber Technique and the Single-Pass Perfusion in Humans

H. Lennernäs, S. Nylander, A.-L. Ungell

Journal:

Pharmaceutical Research

Année:

1997

Fichier:

PDF, 346 KB

1997

14

Comparison Between Permeability Coefficients in Rat and Human Jejunum

Urban Fagerholm, Monica Johansson, Hans Lennernäs

Journal:

Pharmaceutical Research

Année:

1996

Fichier:

PDF, 1.11 MB

1996

15

The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension

Hans Lennernäs, Bertil Abrahamsson

Journal:

Journal of Pharmacy and Pharmacology

Année:

2005

Langue:

english

Fichier:

PDF, 212 KB

english, 2005

16

A comparison between direct determination of in vivo dissolution and the deconvolution technique in humans

Lisbet Bønløkke, Lars Hovgaard, Henning G. Kristensen, Lars Knutson, Anders Lindahl, Hans Lennernäs

Journal:

European Journal of Pharmaceutical Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 215 KB

english, 1999

17

Chitosans as absorption enhancers of poorly absorbable drugs: 3: Influence of mucus on absorption enhancement

Nicolaas G.M. Schipper, Kjell M. Vårum, Patric Stenberg, Göran Ocklind, Hans Lennernäs, Per Artursson

Journal:

European Journal of Pharmaceutical Sciences

Année:

1999

Langue:

english

Fichier:

PDF, 430 KB

english, 1999

18

Replacement therapy of oral hydrocortisone in adrenal insufficiency: the influence of gastrointestinal factors

Lennernäs, Hans, Skrtic, Stanko, Johannsson, Gudmundur

Journal:

Expert Opinion on Drug Metabolism & Toxicology

Année:

2008

Langue:

english

Fichier:

PDF, 272 KB

english, 2008

19

The contribution of food groups to the nutrient intake and food pattern among pre-school children

H. Sepp, L. Abrahamsson, M. Lennernäs Junberger, E. Risvik

Journal:

Food Quality and Preference

Année:

2002

Langue:

english

Fichier:

PDF, 158 KB

english, 2002

20

Comprehensive Medicinal Chemistry II || The Biopharmaceutics Classification System

Année:

2007

Langue:

english

Fichier:

PDF, 297 KB

english, 2007

21

Clinical Pharmacokinetics of Atorvastatin

Professor Hans Lennernäs

Journal:

Clinical Pharmacokinetics

Année:

2003

Langue:

english

Fichier:

PDF, 204 KB

english, 2003

22

Regional intestinal drug permeation: Biopharmaceutics and drug development

Lennernäs, Hans

Journal:

European Journal of Pharmaceutical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 862 KB

english, 2014

23

Intestinal permeability and its relevance for absorption and elimination

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 508 KB

english, 2007

24

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

Dahan, Arik, Miller, Jonathan M., Hilfinger, John M., Yamashita, Shinji, Yu, Lawrence X., Lennernäs, Hans, Amidon, Gordon L.

Journal:

Molecular Pharmaceutics

Année:

2010

Langue:

english

Fichier:

PDF, 552 KB

english, 2010

25

Oral biopharmaceutics tools – Time for a new initiative – An introduction to the IMI project OrBiTo

Lennernäs, H., Aarons, L., Augustijns, P., Beato, S., Bolger, M., Box, K., Brewster, M., Butler, J., Dressman, J., Holm, R., Julia Frank, K., Kendall, R., Langguth, P., Sydor, J., Lindahl, A., McAllis

Journal:

European Journal of Pharmaceutical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 769 KB

english, 2014

26

In silico predictions of gastrointestinal drug absorption in pharmaceutical product development: Application of the mechanistic absorption model GI-Sim

Sjögren, Erik, Westergren, Jan, Grant, Iain, Hanisch, Gunilla, Lindfors, Lennart, Lennernäs, Hans, Abrahamsson, Bertil, Tannergren, Christer

Journal:

European Journal of Pharmaceutical Sciences

Année:

2013

Langue:

english

Fichier:

PDF, 2.63 MB

english, 2013

27

Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development

Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Année:

2014

Langue:

english

Fichier:

PDF, 755 KB

english, 2014

28

Pharmacokinetics of an Injectable Modified-Release 2-Hydroxyflutamide Formulation in the Human Prostate Gland Using a Semiphysiologically Based Biopharmaceutical Model

Sjögren, Erik, Tammela, Teuvo L., Lennernäs, Bo, Taari, Kimmo, Isotalo, Taina, Malmsten, Lars-Åke, Axén, Niklas, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Année:

2014

Langue:

english

Fichier:

PDF, 6.04 MB

english, 2014

29

Correlation of Human Jejunal Permeability (in Vivo) of Drugs with Experimentally and Theoretically Derived Parameters. A Multivariate Data Analysis Approach

Winiwarter, Susanne, Bonham, Nicholas M., Ax, Fredrik, Hallberg, Anders, Lennernäs, Hans, Karlén, Anders

Journal:

Journal of Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 179 KB

english, 1998

30

The Biopharmaceutics Risk Assessment Roadmap for Optimizing Clinical Drug Product Performance

Selen, Arzu, Dickinson, Paul A., Müllertz, Anette, Crison, John R., Mistry, Hitesh B., Cruañes, Maria T., Martinez, Marilyn N., Lennernäs, Hans, Wigal, Tim L., Swinney, David C., Polli, James E., Sera

Journal:

Journal of Pharmaceutical Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 723 KB

english, 2014

31

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Cell Cultures in Drug Discovery: An Industrial Perspective

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Année:

2003

Langue:

english

Fichier:

PDF, 344 KB

english, 2003

32

Nocturnal eating and serum cholesterol of three-shift workers

Maria Lennernäs, Torbjörn Åkerstedt and Leif Hambræus

Journal:

Scandinavian Journal of Work Environment & Health

Année:

1994

Langue:

english

Fichier:

PDF, 785 KB

english, 1994

33

Human in Vivo Regional Intestinal Permeability: Quantitation Using Site-Specific Drug Absorption Data

Sjögren, Erik, Dahlgren, David, Roos, Carl, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Année:

2015

Langue:

english

Fichier:

PDF, 1023 KB

english, 2015

34

The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations

Sjogren, E., Lennernas, H., Andersson, T. B., Grasjo, J., Bredberg, U.

Journal:

Drug Metabolism and Disposition

Année:

2009

Langue:

english

Fichier:

PDF, 679 KB

english, 2009

35

Shift work and health || Eating and shift work — effects on habits, metabolism, and performance

Arne Lowden, Claudia Moreno, Ulf Holmbäck, Maria Lennernäs and Philip Tucker

Journal:

Scandinavian Journal of Work Environment & Health

Année:

2010

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2010

36

Modeling Gastrointestinal Drug Absorption Requires More In Vivo Biopharmaceutical Data: Experience from In Vivo Dissolution and Permeability Studies in Humans

Lennernas, Hans

Journal:

Current Drug Metabolism

Année:

2007

Langue:

english

Fichier:

PDF, 410 KB

english, 2007

37

Regional Intestinal Permeability of Three Model Drugs in Human

Dahlgren, David, Roos, Carl, Lundqvist, Anders, Abrahamsson, Bertil, Tannergren, Christer, Hellström, Per M., Sjögren, Erik, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Année:

2016

Langue:

english

Fichier:

PDF, 958 KB

english, 2016

38

Regional Intestinal Permeability in Dogs: Biopharmaceutical Aspects for Development of Oral Modified-Release Dosage Forms

Dahlgren, David, Roos, Carl, Johansson, Pernilla, Lundqvist, Anders, Tannergren, Christer, Abrahamsson, Bertil, Sjögren, Erik, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Année:

2016

Langue:

english

Fichier:

PDF, 1.70 MB

english, 2016

39

In Vitro Release Mechanisms of Doxorubicin From a Clinical Bead Drug-Delivery System

Ahnfelt, Emelie, Sjögren, Erik, Hansson, Per, Lennernäs, Hans

Journal:

Journal of Pharmaceutical Sciences

Année:

2016

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2016

40

[Methods and Principles in Medicinal Chemistry] Drug Bioavailability || Application of the Biopharmaceutic Classification System Now and in the Future

van de Waterbeemd, Han, Lennernäs, Hans, Artursson, Per

Année:

2003

Langue:

english

Fichier:

PDF, 742 KB

english, 2003

41

Computational fluid dynamics (CFD) studies of a miniaturized dissolution system

Frenning, G., Ahnfelt, E., Sjögren, E., Lennernäs, H.

Journal:

International Journal of Pharmaceutics

Année:

2017

Langue:

english

Fichier:

PDF, 652 KB

english, 2017

42

Regional intestinal permeability in rats: a comparison of methods

Roos, Carl, Dahlgren, David, Sjögren, E., Tannergren, Christer, Abrahamsson, Bertil, Lennernas, H.

Journal:

Molecular Pharmaceutics

Année:

2017

Langue:

english

Fichier:

PDF, 1.08 MB

english, 2017

43

The effects of three absorption-modifying critical excipients on the in vivo intestinal absorption of six model compounds in rats and dogs

David, Dahlgren, Carl, Roos, Pernilla, Johansson, Christer, Tannergren, Anders, Lundqvist, Peter, Langguth, Markus, Sjöblom, Erik, Sjögren, Hans, Lennernäs

Journal:

International Journal of Pharmaceutics

Année:

2018

Langue:

english

Fichier:

PDF, 1.55 MB

english, 2018

44

Mechanistic modelling of intestinal drug absorption – the in vivo effects of nanoparticles, hydrodynamics, and colloidal structures

Roos, C., Westergren, J., Dahlgren, D., Lennernäs, H., Sjögren, E.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2018

Langue:

english

Fichier:

PDF, 621 KB

english, 2018

45

Pulmonary dissolution of poorly soluble compounds studied in an ex vivo rat lung model

Eriksson, Johanna, Thörn, Helena, Sjögren, Erik, Holmstén, Lisa, Rubin, Katarina, Lennernäs, Hans

Journal:

Molecular Pharmaceutics

Année:

2019

Langue:

english

Fichier:

PDF, 1.42 MB

english, 2019

46

The Critical Role of Passive Permeability in Designing Successful Drugs

Di, Li, Artursson, Per, Avdeef, Alex, Benet, Leslie, Houston, Brian, Kansy, Manfred, Kerns, Edward, LennernÃ¤s, Hans, Smith, Dennis, Sugano, Kiyohiko

Journal:

Année:

2020

Fichier:

PDF, 1.27 MB

2020

47

Pulmonary drug absorption and systemic exposure in human: Predictions using physiologically based biopharmaceutics modeling

Eriksson, Johanna, ThÃ¶rn, Helena, LennernÃ¤s, Hans, SjÃ¶gren, Erik

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Année:

2020

Fichier:

PDF, 1.60 MB

2020

48

Pulmonary absorption rate and bioavailability of drugs in vivo in rats: Structure–absorption relationships and physicochemical profiling of inhaled drugs

Ann Tronde, Bo Nordén, Hans Marchner, Anna-Karin Wendel, Hans Lennernäs, Ursula Hultkvist Bengtsson

Journal:

Journal of Pharmaceutical Sciences

Année:

2003

Langue:

english

Fichier:

PDF, 378 KB

english, 2003

49

CYP3A4, CYP3A5, and MDR1 in human small and large intestinal cell lines suitable for drug transport studies

Helena A. Engman, Hans Lennernäs, Jan Taipalensuu, Charlotta Otter, Brith Leidvik, Per Artursson

Journal:

Journal of Pharmaceutical Sciences

Année:

2001

Langue:

english

Fichier:

PDF, 251 KB

english, 2001

50

Pharmacokinetics of gefitinib in humans: The influence of gastrointestinal factors

Ebba Bergman, Patrik Forsell, Eva M. Persson, Lars Knutson, Paul Dickinson, Robert Smith, Helen Swaisland, Matthew R. Farmer, Mireille V. Cantarini, Hans Lennernäs

Journal:

International Journal of Pharmaceutics

Année:

2007

Langue:

english

Fichier:

PDF, 306 KB

english, 2007